Transparante wetenschappelijke onderbouwing van zorg

• GRADE ("Grading of Recommendations Assessment, Development and Evaluation") provides a transparent framework to evaluate scientific evidence and to develop healthcare recommendations.
• The GRADE method has been further developed, its application has been significantly broadened and over 100 organizations have endorsed GRADE.
• In this article, we give an overview of the most important methodological developments and discuss the basic principles. The transparent approach to make it easier for users of evidence to assess the judgments behind recommendations is not only applicable to the EBM domains but also to other disciplines.
• The methods developments show that GRADE is still evolving, and is constantly being further developed based on the latest methodological insights and users perspective.
• GRADE is not an instrument to determine the "true" certainty of the evidence. The value of applying GRADE is that judgments about the quality of evidence and the considerations behind recommendations are structured, transparent and explicit.

Conflict of interest and financial support: potential conflicts of interest have been reported for this article. ICMJE forms provided by the authors are available online along with the full text of this article.