Addison-crisis uitgelokt door substitutietherapie met levothyroxine

L. Dawson, C.G. Schaar, P.H.E.M. de Meijer en A.E. Meinders

Addisonian crisis provoked by substitution therapy with levothyroxine.

A woman aged 36 with a positive family anamnesis for autoimmune endocrine diseases and a history of thyroid diseases, developed major complaints of general malaise, orthostatic hypotension and loss of appetite after the start of a treatment with levothyroxin because of (sub)clinical hypothyroidism. She was found to suffer from primary adrenocortical insufficiency masked by excessive use of liquorice and a lowered metabolism, but which via the suppletion with thyroid hormone had led to an addisonian crisis.