Ziekte van Kawasaki of SARS-CoV-2-gerelateerde MIS-C?

Kawasaki disease (KD) and SARS-CoV-2 related multisystem inflammatory syndrome in children (MIS-C) are clinically overlapping febrile syndromes based on clinical criteria. The diagnostic criterium of positive anti-SARS-CoV-2 serology will become inutile, as many children will have experienced COVID-19 infection or have been vaccinated. Given the risk of cardiovascular complications, alertness and timely treatment of both syndromes is very important in children with multiple days of unexplained fever. The clinically overlapping phenotype and good response to IVIG-based treatment of KD and MIS-C - either without or with prednisolone - suggest a common spectrum of these ‘hyperinflammatory syndromes’ with varying degrees of severity and known triggering factors.

Conflict of interest and financial support: none declared.