Invloed van roken op farmacokinetiek van medicijnen

• In a previous issue, a case report was presented in the Dutch Journal of Medicine (NTvG) of a patient who had variable clozapine levels after switching from regular cigarettes to an e-cigarette and vice versa.
• Besides clozapine there are a number of other agents with a narrow therapeutic range where pharmacokinetics can be influenced by smoking.
• This review describes the mechanisms of smoking-induced influence on the pharmacokinetics of medicines, and guidance will be provided regarding which medicines must be monitored more closely when patients change their smoking habits.
• Finally, an overview is given on package insert information concerning dose adjustments for smokers and non-smokers.

Conflict of interest and financial support: none declared.