Hitteberoerte: pathofysiologie en pathogenese

- The pathophysiology of heat stroke is not fully understood.

- Endotoxins and cytokines appear to play a major part in the central nervous system and in the peripheral tissues.

- Use of specific receptor blockers prior to heat exposure can diminish cerebral damage in animal experiments.

- The energy depletion model of Hubbard gives a possible explanation for the rhabdomyolysis observed in some heat stroke patients. Failure of the ATP dependent Na⁺-K⁺ pump is essential in this theory.