Een blauwe verkleuring van de tenen

A 69-year-old woman presented with progressive gangrene affecting the toes of both feet. Laboratory investigations showed marked thrombocytosis (800 x 109/l). A positive JAK2V617F-mutation confirmed essential thrombocytosis as the underlying cause of the gangrene. With thrombocyte-lowering therapy, platelet counts normalized and the gangrene showed no further progression.

Conflict of interest and financial support: none declared.