De prognostische betekenis van de alkalische- en zure-fosfatasegehalten bij de hormonale behandeling van patiënten met prostaatcarcinoom

– In a group of 146 cases of primary prostatic cancer, diagnosed between 1971 and 1982, the serum levels of alkaline and acid phosphatase had been determined before hormonal treatment was given. We have determined retrospectively whether the level of alkaline and acid phosphatases had any relation with the survival time and the reaction of the prostatic carcinoma to the therapy. It was found that a higher level of alkaline or acid phosphatase is associated with a lower 3- and 5-years survival. Besides, decrease of alkaline or acid phosphatase levels is associated with a better reaction of the prostatic cancer to therapy. Therefore the authors believe that both alkaline and acid phosphatase levels may be used as biochemical parameters which give additional information on the prognosis of prostatic cancer and especially on its reaction to hormonal therapy.