De interactie tussen antistollingstherapie met vitamine K-antagonisten en behandeling met antibiotica: een praktische aanbeveling

- In users of vitamin K-antagonists (VKA), antibiotics can lead to excessive anticoagulation.

- It is unclear what the optimal policy is for prevention of an excessive anticoagulant effect during use of antibiotics.

- This article describes the increased sensitivity to VKA during use of antibiotics, and also provides a practical recommendation for the correct method for use of antibiotics in combination with VKA treatment.

- During use of antibiotics for more than one day, the prothrombin time-‘international normalized ratio’ (PTT-INR) must be checked both after 3 and after 7 days, and the dose of VKA must be adapted if necessary.

- Use of co-trimoxazole for more than one day should, if possible, be avoided.

Ned Tijdschr Geneeskd. 2008;152:1042-6