Verbetering in de 5-jaarsoverleving na leverresectie voor colorectale metastasen in het Erasmus MC over de periode 1984-2006

Objective

To determine the survival rates of patients with colorectal hepatic metastases following curative hepatic resection.

Design

Retrospective.

Method

Data were collected on all patients who underwent hepatic resection during the period 1984-2006. Disease-free survival and overall survival were determined and prognostic factors for total survival were evaluated using multivariate analysis. The year 2000 was arbitrarily chosen as a dividing line, in order to compare results before and after the introduction of multi-modular treatment methods.

Results

In total, 396 patients underwent a hepatic resection with curative intent. From 2000 onwards these were performed in the presence of a larger number of metastases (median 2 versus 1; p = 0.013). The diameter of the resected metastases was smaller (median 3 cm versus 4 cm; p

Conclusion

5-year survival rates following hepatic resection with curative intent for colorectal metastases were statistically significantly better for operations carried out after 2000 despite similar disease-free survival.