Nieuwe geneesmiddelen; erlotinib

- Erlotinib inhibits the phosphorylation of the epidermal growth-factor receptor (EGFR/HER1), a tyrosinekinase protein. This results in an inhibition of signal transduction and therefore decreased cell division and increased cell death. The agent is indicated for the treatment of patients with advanced local or metastasised non-small-cell pulmonary carcinoma after other cytostatic therapy has failed.

Ned Tijdschr Geneeskd. 2006;150:2703-4