Lokale tumorcontrole en (ziektevrije) overleving na chirurgie met pre- en intraoperatieve radiotherapie voor primair irresectabel rectumcarcinoom en locoregionaal recidief

Survey of the results of multimodality treatment for primary irresectable rectum carcinoma and local recurrence of rectal cancer.

Design

Retrospective.

Methods

During the period 1 February 1994 to 31 August 1999, 43 patients with locally advanced primary rectal cancer (25 men and 18 women; mean age: 64 years (range: 36-86)) and 53 patients with a local recurrence (33 men and 20 women; mean age: 61 years (39-82)) were treated with a multimodality treatment: i.e. preoperative radiotherapy (doses 50.4 Gy, or 30.0 Gy in the case of reirradiation), extensive surgery and intraoperative radiotherapy (doses 10-17.5 Gy). This treatment took place at two hospitals in the Netherlands, the Catharina Hospital in Eindhoven and, since 1997, the Daniel den Hoed Cancer Centre in Rotterdam. In 2000 data were collected for the local control and (disease-free) survival; these were analysed using the Kaplan-Meier method. Patients also completed a questionnaire about the quality of life at a median period of 14 months (range: 4-60) after the operation; the response level was 96 (76/79).

Results

After 3 years, the local control, disease-free survival and survival rates for the locally advanced primary rectal cancer group were 74, 60 and 55 respectively, and for the locally recurrent rectal cancer group 64, 34 and 50 respectively. Tumour resection with microscopically negative margins had a statistically significant positive effect on the local control and disease-free survival in both groups as well as on the survival in the locally advanced primary patient group. Seven of the 96 patients (7) died as a result of complications. Of the patients with a primary irresectable carcinoma or a local recurrent tumour who completed the questionnaire the results were as follows: 56 and 63 respectively had been able to resume employment, 53 and 59 respectively had been able to resume their previous lifestyle, 15 and 27 respectively indicated radicular pain as a new symptom, 26 and 46 respectively stated problems with walking, 42 and 44 respectively stated problems with urinating and 59 and 52 respectively a reduction in sexual activity.