Een hevig spugende zuigeling met profuse diarree

Background

Food protein-induced enterocolitis is a manifestation of non-IgE-mediated cow’s milk allergy, characterized by acute vomiting and profuse diarrhoea. This reaction is often not recognized as cow’s milk allergy.

Case description

We present a 6-week-old, formula-fed girl with frequent vomiting, diarrhoea and failure to thrive. These symptoms disappeared after giving cow’s milk-free formula. Forty-five minutes after the last dose in a non-blinded provocation test with cow’s milk, she developed profuse diarrhoea and vomiting, resulting in hypovolemic shock. No specific IgE against cow’s milk was found.

Conclusion

Unusual in this case is the severe but relatively late reaction to the provocation test. In an acutely ill infant with vomiting, diarrhoea and pallor – which can even result in shock – food protein-induced enterocolitis as manifestation of non-IgE-mediated allergy must be considered. These symptoms start as late as 2 to 3 hours after exposure and disappear after withdrawal of the causal product.

Conflict of interest: none declared. Financial support: none declared.