Nieuwe bijwerkingen van protonpompremmers

Large population studies published recently have revealed additional risks of chronic use of proton pump inhibitors (PPIs). Dementia and renal failure were reported as long-term follow-up side effects of chronic use, in addition to the previously known increased risk for various infections, osteoporosis and metabolic disturbances. In the light of ongoing over-prescription of PPIs, this should lead to reconsideration of individual indications.

Conflict of interest and financial support for this article: N.J. de Wit’s institution received from 1996 to 2006 research grants from the Netherlands Organisation for Health Research and Development (ZonMw) for research on dyspepsia management, and unrestricted grants from Altana Pharma and Janssen for research on reflux disease and dyspepsia; M.E. Numans’ institute received a research grant from ZonMw from 1997 to 2006, and unrestricted research grants from AstraZeneca, Altana Pharma and Janssen-Cilag from 1996 to 2007. ICMJE forms provided by the authors are available online along with the full text of this article.