Kinderen met obesitas en afbuigende lengtegroeicurve: ziekte van Cushing?

We describe two children who presented with extreme weight gain and failure to grow in height, and who were both diagnosed with Cushing’s disease. Following preoperative metyrapone treatment, both children successfully underwent curative transsphenoidal surgery. While obesity is a common and increasing problem in childhood, Cushing’s disease is rare. The combination of weight gain and growth failure in a child is an alarming sign in which underlying endocrine disease must be ruled out.

Conflict of interest: interests are declared. A disclosure form provided by the author is available with the full text of this article at www.ntvg.nl, search for A4677; click on ‘Belangenverstrengeling’ (‘Conflict of interest’). Financial support: none declared.