Geen onderbouwing voor maximale leeftijdsgrens voor mannen bij in-vitrofertilisatie of intracytoplasmatische sperma-injectie

To identify medical and psychosocial risks that could arise from allowing older men to father children through in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI).

Design

Literature review.

Method

The databases Medline, Current Contents weekly, Current Contents archives, and PsycINFO were searched over the period 1970-June 2004 for articles with data on age limits for men entering IVF/ICSI programmes. The following inclusion criteria were used: availability in the Netherlands and written in English or Dutch.

Results

Although sperm quality decreases with age, men remain fertile up to an advanced age. The risks of having children with autosomal dominant disorders or chromosomal defects increase slightly, but the individual chance is extremely small. Studies on the psychological development of children with fathers aged > 50 years are lacking. Extrapolation from other studies indicates that growing up with an older father has no negative influence on child development. Although older fathers have a greater chance of dying sooner, the absence of the father does not contribute significantly to psychological problems in offspring later in life.

Conclusion

There are no medical or psychosocial arguments to support an age limit for men entering an IVF/ICSI programme.

Ned Tijdschr Geneeskd 2005;149:992-5