Factor X-deficiëntie bij AL-amyloïdose

Background

An acquired bleeding tendency is a specific symptom that can indicate an underlying disease.

Case description

Here we describe a 69-year-old patient with an acquired bleeding tendency resulting from a factor X deficiency due to an underlying amyloid light-chain (AL) amyloidosis. Factor X deficiency in AL amyloidosis arises from a quantitative and qualitative deficiency of factor X because it binds to amyloid fibrils exposed to circulating blood.

Conclusion

Bleeding tendency is a rare complication of AL amyloidosis, often resulting from a factor X deficiency.

Conflict of interest and financial support: disclosure forms provided by the authors are available along with the full text of this article at www.ntvg.nl; search for A6678, click on ‘Belangenverstrengeling’ (‘Conflict of interest’).