Diagnose en verloop van vroege artritis; onderzoek op een gespecialiseerde polikliniek voor vroege artritis

To investigate the occurrence, diagnosis and course of all new inflammatory arthropathies seen in a special Early Arthritis Clinic (EAC).

Design

Prospective cohort study.

Setting

Academic Medical Hospital, Leiden, the Netherlands.

Methods

An Early Arthritis Clinic (EAC) was started in the outpatient clinic of rheumatology of Leiden University Hospital for diagnostic work-up according to protocol of patients with recent-onset arthritis. Inclusion criteria were: active arthritis with onset < 2 years without traumatic aetiology and no referral for a second opinion.

Results

In the first 18 months 276 patients were sent to the EAC, 212 met the inclusion criteria. After 2 weeks the following diagnoses were made: rheumatoid arthritis (RA) (58; 28), psoriatic arthritis (8; 4), reactive arthritis ( 11; 5), sarcoidosis (9; 4), crystal arthritis (30; 14), osteoarthritis (8; 4), other diagnoses (18; 8). The remaining 70 patients (33) were classified as arthritis e causa ignota (e.c.i.). After follow-up, the first diagnosis changed in 27 (12) patients, of whom 20 patients originally had had the diagnosis of arthritis e.c.i. Persistent arthritis was found in 90 of RA and in 35 of arthritis e.c.i. Other forms of arthritis seldom showed persistent activity.

Conclusion

In the EAC, RA, arthritis e.c.i. and crystal arthritis were seen most often. Almost all RA patients showed persistent arthritis, as against only a third of those with arthritis e.c.i. Because of the early diagnosis treatment could start early in patients with joint disease entailing irreversible joint destruction.