Ascites, hydrothorax en ovariumtumor: syndroom van Meigs, bij een patiënte met kleine ovaria en gestegen CA 125-waarde

– In a 51-year-old woman with bilateral Brenner tumours of the ovaries and with intermittent hydrothorax and ascites, Meigs’ syndrome was diagnosed. The serum CA 125 level was 620 Uml (normal: 5-35). Bilateral ovariectomy, hysterectomy and omentectomy were carried out. The ovaries were not enlarged. Postoperatively, the pleural effusion and ascites resolved and the CA 125 level decreased to 8.4 Uml. The pathogenesis of hydrothorax probably involves passage through the diaphragm, and the CA 125 may be produced by the peritoneal lining or by the Brenner tumours.