Allergie voor humaan semen

- Two women aged 29 and 27 years, with complaints ranging from itching and swelling during or after cohabitation to anaphylactic symptoms comprising generalized urticaria, angioedema and dyspnoea, were found to be allergic to human semen. The total amount of serum IgE had increased in both, and the amount of semen albumin-specific IgE in one of them; both showed a positive reaction to an intracutaneous test with seminal plasma. The women were given a course of hyposensitization treatment, after which the problems disappeared.