‘Therapeutic drug monitoring’ van antimicrobiële middelen

• The importance of dose adjustments of antimicrobials based on measured concentrations in an individual (‘therapeutic drug monitoring’, TDM) is increasingly recognized. There are several reasons for this.
• First, there is a better understanding of the relationships between doses administered, concentrations achieved and effects of antimicrobials.
• Second, adverse events from antimicrobials and their relationship to drug concentrations are better described.
• Third, analytical methods to measure concentrations have become more widely available.
• In this article, we provide an overview of the situation of available antimicrobials in the Netherlands for which TDM is or could be indicated.

Conflict of interest and financial support: ICMJE forms provided by the authors are available online along with the full text of this article.