Sequentiële analysen in klinisch en epidemiologisch onderzoek

- In clinical trials and epidemiological studies, interim analyses are usually performed for ethical or economical reasons, although efficiency aspects can also be a reason. The analysis is referred to as group-sequential analysis or continuous-sequential analysis, dependent on the number of interim analyses performed.

- Repeated testing of cumulative data requires an adjustment to the significance level or type I error α of a statistical test.

- On average a (group-)sequential analysis of a clinical or epidemiological study requires less patients than the analysis of a fixed-sample study.