Radio-immunotherapie bij het B-cel-non-hodgkinlymfoom

– Radio-immunotherapy is a new treatment modality for patients with B-cell non-Hodgkin lymphoma.

– In radio-immunotherapy, a therapeutic radionuclide is coupled to a monoclonal antibody directed against a tumour-specific or tumour-associated antigen.

– Biodistribution studies and dosimetry are used in the planning of radio-immunotherapy.

– Clinical studies, notably in patients with indolent non-Hodgkin lymphoma, have demonstrated the clinical feasibility and efficacy of this treatment.

– The use of a high dose of radio-immunotherapy in combination with (high-dose) chemotherapy and peripheral stem-cell transplantation constitutes a supplemental treatment for patients who respond insufficiently or not at all to standard therapy.

– The exact place of radio-immunotherapy in the treatment of patients with non-Hodgkin lymphomas is not yet clear.

Ned Tijdschr Geneeskd. 2005;149:2324-8