Ovariumcarcinoom stadium I en II: de betekenis van radiotherapie van het gehele abdomen

– In the period from 1981 to 1986 85 patients with ovarian carcinoma stage I and II were treated in a prospective study. All patients underwent primary surgery: bilateral salpingo-oophorectomy, hysterectomy and omentectomy followed by a staging procedure. In 46 patients the staging was completed by a retroperitoneal lymph node dissection, whereas in 39 patients this procedure was omitted. Total abdominal irradiation (25 Gy1.50 Gy per fraction) was followed by a pelvic booster dose (25 Gy1.75 Gy per fraction). Patients with stage I and IIa wel differentiated tumours received no adjuvant radiotherapy and are not reported here. The 5-year actuarial recurrence-free survival rate for the irradiated group was 75. Stage according to FIGO appeared to be of significant prognostic influence. There was no difference in survival between completely and incompletely staged patients. Serious (small) bowel complications occurred however in 6 out of 45 patients who had undergone complete staging.