Onvoldoende therapietrouw bij ziekte van Parkinson

Stand van zaken
Marjolein B. Aerts, Martijn van der Eijk, Kees Kramers en Bastiaan R. Bloem

Insufficient medication compliance in Parkinson’s disease

Conflict of interest: none declared. Financial support: Prof. B.R. Bloem was supported by a NWO-VIDI grant (no. 91776352) and M.B. Aerts by the International Parkinson Fund Foundation and the ‘Van Alkemade Keuls’ fund.

  • Medication compliance is generally suboptimal, particularly in patients with complex polypharmacy. This generic treatment problem is described here for Parkinson’s disease (PD).

  • We would expect patients with PD to have good medication compliance, since missed doses immediately result in worsening of symptoms. However, recent research has revealed that PD patients demonstrate poor medication compliance.

  • Poor medication compliance is particularly undesirable for patients with PD because regular intake of medication is required for optimal treatment effect.

  • Possible ways of improving medication compliance are pharmacotherapeutic measures and behavioural interventions. Modern methods of communication (text message reminders) and ‘smart’ pill dispensers may be beneficial, but the advantages of such interventions have not yet been scientifically studied.