Leverbeschadiging door geneesmiddelen

– The importance of voluntary reporting of adverse effects of drugs is discussed for the case of clinicopathological patterns of hepatic injury by glafenine, ketoconazole, nitrofurans and pirprofen. The detection of unknown, rare but serious side effects is an important goal of postmarketing surveillance. Well-documented case reports of already known side effects form the source of useful additional information on the relative frequency of the different clinicopathological patterns with which a particular adverse reaction to a particular drug may present itself. The only way to study rare, serious side effects is by pooling series of cases. Such series may also serve as a starting point for studies on mechanisms and diagnostic methods. Adequate documentation of an adverse reaction is possible if it is reported while clinical signs and symptoms are still present.