Klinische betekenis van laboratoriumtesten SARS-CoV-2

Stand van zaken
Jaap Goudsmit, Fransje W. van der Waals, Joost Swart en Frank de Wolf

Clinical meaning of laboratory tests for SARS-CoV-2

  • In the Netherlands, as of 1 June 2020, everyone with symptoms associated with COVID-19 is entitled to be tested for presence of the virus in the nasopharyngeal cavity; at the same time, tests for antibodies in peripheral blood will become available.
  • We review current knowledge regarding screening for virus particles in a cotton swab smear taken from the nasopharyngeal cavity or in saliva, on the appearance of SARS-CoV-2 antibodies in blood, as well as on the interpretation of test results.
  • Based on the virological and serological course, we distinguish an acute infection from a recent or resolved infection.
  • We discuss how to identify different probabilities of infectiousness and the connection between seropositivity for SARS-CoV-2-specific antibodies and immunity against re-infection.

Conflict of interest and financial support: none declared.