Incidentie van baarmoederhalskanker even groot na een negatief uitstrijkje met of zonder endocervicale cellen

To determine the prognostic relevance of the absence of endocervical cells in a preventive cervical smear with respect to the later development of histologically established neoplastic cervical lesions.

Design

Longitudinal and retrospective.

Method

All negative smears (n = 448,983), taken in 1990 and 1991 in the Netherlands, were retrieved from the Dutch Network and National Database for Pathology (PALGA), along with all cytological and histological examinations taken after negative smears until April 1998.

Results

No significant differences were detected between the proportion of preinvasive lesions (cervical intraepithelial neoplasia 1, 2 and 3) after negative smears without endocervical cells (n = 53,142) compared to negative smears with endocervical cells (n = 395,841; odds ratio 0.93, 0.99 and 1.06, respectively). The proportion of women who developed invasive cervical cancer during the follow-up of 6.25-8.25 years was the same in both groups (odds ratio: 0.97; 95 CI: 0.65-1.44).

Conclusion

These data suggest there is no reason for advising women with negative smears which do not contain endocervical cells, to have an additional smear.