Hoge concentratie van stollingsfactor VIII als risicofactor voor trombose

- Several case-control studies have shown that factor VIII levels ≥ 150 IU/100 ml lead to a greatly increased risk of venous thrombosis. High levels of factor VIII are also associated with an increased risk of recurrences of thrombosis.

- The prevalence of high factor VIII levels is 25 in patients with a first episode of venous thrombosis and 11 among healthy controls. The contribution of high factor VIII levels to the onset of venous thrombosis in the population is 16.

- The mechanism causing high factor VIII levels is largely unknown and probably consists of both genetic and acquired factors.

- At present, the routine screening of thrombosis patients for high factor VIII levels is not recommended.