Het ductale carcinoma in situ van de mamma; een klinisch-pathologisch retrospectief onderzoek

– A retrospective clinico-pathological study was made of 45 patients who had been subjected to mastectomy because of duct carcinoma in situ in the Netherlands Cancer Institute (Antoni van Leeuwenhoekhuis), between 1956 and 1984. Thirty-four patients had a follow-up of at least 5 years (mean 9.2 years); none of them had died of the disease. It was found that cytological and frozen-section examination are of only limited diagnostic value. Most lesions are found to be more extensive than had been suspected on clinical and radiological grounds. After excisional biopsy, a tumour rest often remained behind. Histological examination can never exclude infiltrative growth with certainty, but the risk of lymph-node metastases is extremely small. The possibilities of breastpreserving therapy are discussed.