Herhaalde miskramen en trombofilie

- In more than half of the couples with recurrent miscarriage, no underlying cause can be found.

- Both acquired and hereditary risk factors for venous thrombosis, i.e. thrombophilia, constitute an aetiologic factor in a minority of patients with recurrent miscarriage.

- In women with a diagnosis of antiphospholipid antibody syndrome, treatment with low-dose acetylsalicylic acid and low-molecular-weight heparin has been shown by a valid randomised controlled trial to improve the results of a subsequent pregnancy.

- However, it is unknown whether anticoagulant treatment of women with recurrent miscarriage and hereditary risk factors for thrombophilia improves the outcome of a subsequent pregnancy.

Ned Tijdschr Geneeskd. 2006;150:189-93