Een vrouw met het ‘restless genital’-syndroom

Een moeilijk behandelbaar probleem
Symen K. Spoelstra, Marcel D. Waldinger, Esther R. Nijhuis en Willibrord C.M. Weijmar Schultz

A woman with restless genital syndrome: a difficult-to-treat condition


Restless Genital Syndrome (RGS) refers to the experience of excessive and persistent sensations of genital arousal, with either restless legs and/or complaints of overactive bladder, in absence of conscious feelings of sexual desire. RGS is caused by a small fiber sensory neuropathy of the dorsal nerve of the clitoris, an endbranch of the pudendal nerve. To date, there is no international consensus on the treatment of RGS. Current interventions are based on symptom relief. Literature on the subject contains mostly case reports.

Case description

A 58-year-old woman with a persistent, intrusive and unwanted genital arousal. The sensation is described as pulsating and/or tingling in the genital area, more specifically the clitoris and labia minora. Despite the pre-orgasmic feelings, orgasm was not spontaneously achieved. The arousal symptoms were accompanied by restless legs. Masturbation did not resolve symptoms. Two months prior of onset of symptoms a presacral abscess was drained. This patient benefitted mostly from a combination of clonazepam and psychotherapeutic interventions. Her condition is currently stable and manageable.


Lidocaine, oxazepam, clonazepam, tramadol and TENS, combined with psychotherapeutic counselling, have been described as possible treatment modalities for RGS.

Conflict of interest: none declared. Financial support: none declared.

This supplementary information is presented as submitted by the corresponding author. It has not been copy-edited by NTvG.