Een familie met hereditaire sferocytose, ontdekt na een infectie met het humane parvovirus B19

J. van der Weide, H.J. Dijkhuis, C.M.E. Kremer en R.J. Kraaijenhagen

A family with hereditary spherocytosis detected after a human parvovirus B19 infection.

– Hereditary spherocytosis was diagnosed in five of six children in one family after a human parvovirus B19 (B19-virus) infection. The diagnosis was made on the basis of severe anaemia, demonstrable haemolysis, decreased osmotic fragility and an increased number of spherocytes. Since in the serum of the patients an increased level of IgG and IgM antibodies against B19 virus was detectable two weeks after the crisis it was concluded that the B19-virus infection caused the severe anaemia.