Diagnostiek en behandeling van het korsakovsyndroom

Stand van zaken
Sanne J. van Rhijn, Iris Zijlstra en Haike E. van Stralen

Diagnosis and treatment of Korsakoff’s syndrome

  • Korsakoff’s syndrome is characterised by severe irreversible amnesia and is caused by a thiamine (vitamin B1) deficiency.
  • Korsakoff’s syndrome can also occur in patients without a history of alcohol abuse or Wernicke encephalopathy.
  • Korsakoff’s syndrome is a clinical diagnosis; abnormalities seen on imaging and neuropsychological testing may support the diagnosis.
  • It is vital that the patient stops using alcohol to prevent further cognitive decline.
  • Current literature does not support advising pharmacological treatment other than oral supplementation with thiamine 50 mg twice a day.
  • Neuropsychological methods of treatment, aiming to compensate for impaired cognitive function, have shown promising results.

Conflict of interest and financial support: none declared.