De erfelijkheid van obsessieve-compulsieve stoornissen

Stand van zaken
D.A.J.P. Denys en D.C. Cath

The inheritance of obsessive-compulsive disorders

- Obsessive-compulsive disorder is a chronic psychiatric disorder characterised by obsessions and/or compulsions.

- Genetic research into obsessive-compulsive disorder is significantly limited by the difficulty in clearly defining the disease. There are only a few good studies and the populations investigated are small.

- Family and twin studies have provided evidence for a genetic component in obsessive-compulsive disorders.

- Segregation analyses suggest Mendelian inheritance of a dominant allele. In addition to one gene with a major effect, genes with smaller effects also play a role.