Möbiussyndroom na maternaal misoprostolgebruik

This case report describes a newborn with clinical and radiological features compatible with Moebius syndrome following first-trimester maternal use of misoprostol intended for medical abortion. Despite early vaginal bleeding, the pregnancy continued and the parents opted to proceed. Prenatal ultrasound showed bilateral clubfeet, and postnatal examination revealed cranial nerve dysfunction, hypotonia, and feeding difficulties. An MRI of the cerebrum demonstrated hypoplasia of the pons, thalamic fusion, and absence of the nervus abducens and nervus facialis, findings that support a diagnosis of Moebius syndrome. The report highlights the association between early gestational misoprostol exposure and congenital anomalies, which may not be detectable via prenatal imaging. Counseling and multidisciplinary follow-up are essential. Although the absolute risk is low, clinicians should remain aware of the teratogenic risks after misoprostol exposure.

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